他汀类和烟酸类降脂药物联合应用治疗心血管疾病

Combination niacin and statin therapy in primary and secondary prevention of cardiovascular disease

单独使用他汀类降脂药治疗时,许多患者的血浆脂蛋白达不到治疗目标,尤其是在多项血脂不正常的患者中,他汀类只能轻度的增高高密度脂蛋白(HDL-C):一种独立预测冠心病的因素和轻度的降低甘油三酯(TG)的作用。烟酸对增高HDL和降低TG有明显的药理作用。他汀类和烟酸类合用可以帮助患者控制低密度脂蛋白胆固醇(LDL-C)和升高HDL-C。

Statin monotherapy may not be sufficient to reach serum lipid goals in many patients, especially in those with combined lipid abnormalities. Statins cause only a modest increase in high-density lipoprotein cholesterol （HDL）-an established independent protective factor for coronary heart disease （CHD） and a modest decrease in triglycerides（TG）. Niacin is an effective pharmacologic agent for increasing HDL, as well as lowering TG. Used in combination with a statin, niacin provides an aption to help patients decrease HDL goals.