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核心蛋白聚糖与肾间质纤维化的关系

Relation of decorin and renal interstitial fibrosis
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摘要 核心蛋白聚糖是一种富含亮氨酸的小分子蛋白聚糖,是细胞外基质的组成成分,广泛分布于人和动物的肌腱、皮肤、肾、软骨、脐带、韧带及角膜等各种组织。近年研究表明,它在肾间质纤维化中起重要作用,主要通过抑制肾小管上皮细胞凋亡及拮抗转化生长因子-β的活性与表达,在肾间质纤维化的防治过程中具有广阔的前景。 Decorin, a small leucine-rich proteoglycan, is an important component of extracellular matrix. Decorin is present in kinds of human or animal tissues, such as muscle tendon, skin, kindney, cartilage, umbilical cord, ligaments, cornea and so on. Researches in recent years have indicated that decorin plays an im- portant role in renal interstitial fibrosis through inhibiting renal tubular epithelial cell apoptosis and antagonizing transforming growth factor-β （TGF-β）. It possesses extensive perspective in preventing and treating renal interstitial fibrosis.
作者 袁红霞 孙洞箫
机构地区 辽宁医学院附属第一医院肾内科
出处 《国际内科学杂志》 CAS 2007年第2期112-115,共4页 International Journal of Internal Medicine
关键词 核心蛋白聚糖 肾间质纤维化 转化生长因子-Β Decorin Renal interstitial fibrosis Transforming growth factor-β
分类号 R692 [医药卫生—泌尿科学]
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参考文献18

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二级参考文献10

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国际内科学杂志
2007年 第2期

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