我国汉族人群血管紧张素转换酶基因多态性与原发性高血压关系的Meta分析

Meta-analysis on the Association between Angiotensin Converting Enzyme Gene Polymorphism and Essential Hypertension

[目的]探讨我国汉族人群血管紧张素转换酶（ACE）基因多态性与原发性高血压（EH）的关系。[方法]应用Meta分析方法对国内有关汉族人群共计1678名原发性高血压患者和1630名正常对照的ACE基因多态性与原发性高血压关系的15个研究结果进行综合定量分析。用随机效应模型（D．L法），计算合并比值比OR及其95％的可信区间（95％CI）。[结果]基因型DD，（ID,II）、等位基因（D／I）分布的合并OR分别为1．78（95％CI：1．30～2．78）和1．24（95％CI=1．03～1．49）。[结论]我国汉族人群中带有DD基因型以及D对位基因的个体容易患原发性高血压。

[ Objective ] To study the relations between angiotensin converting enzyme （ ACE ） gene polymorphism and essential hypertension in the Han nationality in China. [ Methods ] 15 separated studies on the relation between ACE gene polymorphism and essential hypertension in China were analyzed by Meta-analysis. Random effect model was selected to calculate the pooled odds ratio（ ORs ）and its corresponding 95% confidence interval（ 95% CI）. [ Results ] The pooled OR for frequency of genotypes and allele were 1.78 （ 95%CI： 1.30-2.78 ） and 1.24 （ 95%CI： 1.0371.49 ） respectively. [ Conclusion ] The DD genotype and D allele of ACE gene may be risk factors for essential hypertension.