亚低温治疗中颅脑温度场的三维数值模拟和实验研究

3D numerical simulation of brain temperature distribution and exprimental research during mild hypothermia therapy

研究了亚低温治疗过程中颅脑温度场的变化规律及影响因素并提出降低颅脑温度的有效方法。基于Pennes生物传热方程,利用有限容积法建立颅脑传热的三维球坐标模型,数值方法求解亚低温治疗过程中颅脑内部的温度变化规律,通过活体动物试验对该方法进行评价,并分析模型中主要参数:血液灌注率、新陈代谢率和动脉血液温度对颅脑温度分布的影响。通过数值计算,得到不同情况下颅脑的温度分布,给出降低脑温的有效方法。所建模型较真实反映了实际颅脑温度变化,数值模拟结果对亚低温治疗的深入探讨具有参考价值。

To study the variation of brain temperature during mild hypothermia therapy and to find out an efficient method for cooling brain, a 3D mathematical model of brain heat-transfer in spherical coordinate system was developed with the limited volume method, based on the Pennes Bioheat Transfer Equation. Numerical simulation of the variation of brain temperature during the mild hypothermia therapy was conducted. The numerical method was also evaluated by means of live animal experiment. Several key parameters which influence the distribution of brain temperature, including haemoperfusion rate, metabolism rate and arterial blood temperature, were also analyzed in the model. From the results of numerical simulation, the distribution of brain temperature in different circumstances was obtained, and an efficient method for cooling brain was suggested. The established model can comparably reflect the real distribution of brain temperature. The results of numerical simulation are useful for studying the mild hypothermia therapy.