混料设计在SAS软件中的实现及其在优化断血流分散片处方配比中的应用

The Accomplishment of Mixture Design with SAS Software and Its Application in Optimizing the Proportion of Technology Prescription of Duanxueliu Dispersible Tablets

目的:介绍混料设计在SAS软件中的实现过程及其在优化断血流分散片制剂工艺成型处方中的应用。方法:以分散均匀性、吸光度为指标,采用混料设计试验对断血流分散片处方中药粉、填充剂(微晶纤维素)、崩解剂(交联聚维酮和低取代羟丙基纤维素)的配比进行优化。结果:优化试验共进行了10组,通过直观分析确定断血流分散片的最佳工艺处方为药粉∶微晶纤维素∶交联聚维酮∶低取代羟丙基纤维素=55∶22.5∶16∶4,此条件在验证试验中得到了证实。结论:应用混料设计优化分散片工艺处方配比,可大大减少试验次数,且结果直观、准确。

Purpose：Introduce an useable method of mixture design in breaking in realization with SAS software and optimizing the handicraft molding prescription of Herba Clinopodii Dispersible Tablets. Method：Compare with disperse homogeneity,attract luminosity being indexs, adopt a trial of mixture design to optimize agents of the handicraft molding prescription of Herba Clinopodii Dispersible Tablets, to include bulking agent （cellulose microcrystallisate, MCC）, disintegrating agent （ polyvinylpolypyrrolidone, PVPP and low - substituted hydroxypropyl cellulose, LHPC）. Result： Carry out optimizing trial 10 sets together, get the best handicraft molding prescription, MCC： PVPP： LHPC = 55 ： 22.5 ： 16 ： 4. Conclusion： Use mixture design to optimize the handicraft molding prescription of dispersible tablets, we can reduce the trial times and the results