3DONOHUE JF, VAN NOORD JA, BATEMAN ED,et al. A 6- month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmenterol [ J ]. Chest,2002,122 ( 1 ) :47 - 55.
4CASABURI R,MAHLER DA,JONES PW, et al. A long term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease [ J]. Eur Respir J,2002,19 (2) :217 - 224.
5BRUSASCO V, HODDER R, MIRAVITLLES M, et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD [ J ]. Thorax, 2003,58 ( 5 ) : 399 - 404.
6JONE PW,QUIRK FH, BAVEYSTOCK CM,et al. The St George's respiratory questionaire [ J ]. Respir Med, 1991,85 ( Suppl B) : S25 - S31.
7DISSE B, SPECK GA, ROMINGER KL, et al. Tiotropium ( Spiriva) :mechanistical considerations and clinical profile in obstructive lung disease[J]. Life Sci,1999,64(6-7) :457 -464.
8VINCKEN W, VAN NOORD JA, GREEFHORST AP,et al. Improved health outcomes in patients with COPD during one year treatment with tiotropium [ J ]. Eur Respir J, 2002,19 (2) : 209 - 216.
9TASHKIN DP. Is a long-acting inhaled bronchodil the first agent to use in stable chronic obstructive pulmonary disease? [ J]. Curt Opin Pulm Med,2005,11 ( 2 ) : 121.
