摘要
本实验以２５μｇ／ｍｌ、５０μｇ／ｍｌ、１００μｇ／ｍｌ为石英终浓度与健康大鼠得来的肺Ⅱ型细胞共同培养２４ｈ，测得细胞培养体系（细胞和培养液）中总磷脂含量升高，培养液中前列腺素Ｅ２（ＰＧＥ２）增加，推测这种变化促进肺组织的非特异性炎症，在矽肺病变形成中具重要作用。
Isolated and purified type Ⅱ alveolar cells from healthy Wistar rats were exposed to different doses of silica from 25-100 μg/ml for 24 hours in culture medium. The results showed that silica could stimulate the secretion of phospholipid and PGE2 of type Ⅱ alveolar cells. This result suggested that the type Ⅱ alveolar cell could accelerate pulmonary inflammation.
出处
《工业卫生与职业病》
CAS
CSCD
1996年第4期196-198,共3页
Industrial Health and Occupational Diseases
关键词
石英
肺泡Ⅱ型细胞
总磷脂
矽肺
Silica, Type Ⅱ alveolar cell, Phospholipid,PGE_2
