脂质体包封EDTA对HgCl_2染毒小鼠SOD活性影响的研究

STUDY ON EFFECT OF LIPOSOME-EDTA ON SOD ACTIVITY IN MICE INTOXICATED WITH HgCl_2

本文测定了实验性ＨｇＣｌ２染毒小鼠ＳＯＤ活性变化及应用脂质体包封ＥＤＴＡ（Ｌｉｐｏｓｏｍｅ－ＥＤ－ＴＡ）和直接ＥＤＴＡ治疗前后的ＳＯＤ活性恢复情况。结果表明，正常小鼠血清ＳＯＤ活性为０．７０９６±０．１８３５μｇ／ｍｌ，汞染毒小鼠血清ＳＯＤ活性为０．３７９３±０．０８４９μｇ／ｍｌ．显示汞染毒小鼠血清ＳＯＤ活性显著降低（Ｐ＜０．０１）。直接应用ＥＤＴＡ治疗后血清ＳＯＤ活性略有恢复（与正常鼠ＳＯＤ比较Ｐ＜０．０５），而应用Ｌｉｐｏｓｏｍｅ－ＥＤＴＡ治疗后ＳＯＤ恢复明显，已接近正常鼠水平（与正常鼠ＳＯＤ比较Ｐ＞０．０５），提示Ｌｉｐｏｓｏｍｅ－ＥＤＴＡ可能具有较强的驱汞作用。

The SOD activities in mice before and after HgCl2 intoxication were determined.The results showed that the activities in normal mice were 0.7096±0.1835μg/ml,and those in intoxicated mice were 0. 3793 ± 0.0849μg/ml which were significantly decreased comparing with normal mice. Then the activities of serum SOD in experimental mice treated with HgCl2 before and after administration of Liposome-EDTA or EDTA alone were determined.After using EDTA alone the activities of serum SOD raised slightly (P<0.05),yet after using Liposome-EDTA the activities raised significantly,approaching those in the normal mice(P>0.05).The results suggested that Liposome-EDTA has a marked effect on elimination of mercury from the body.