氟对大鼠抗氧化酶系统的影响及“抗氟灵”的拮抗作用研究

STUDY ON EFFECT OF FLUORIDE ON ANTI-OXIDASE SYSTEM IN RATS AND ANTAGONISM TO FLUORIDE BY"KANGFULING

选健康雄性Ｗｉｓｔａｒ大鼠４０只，随机分为５组，Ａ组为对照组饮自来水，Ｂ、Ｄ、Ｅ组饮１８０ｍｇＦ／Ｌ溶液，Ｃ组饮相同氟浓度＋２４ｓ％“抗氟灵”混合液。为期２个月，处死Ａ、Ｂ、Ｃ三组，检测相应指标；Ｄ组改饮自来水，Ｅ组改饮２４ｇ％“抗氟灵”，继续观察１个半月，处死，检测相应指标。结果表明，氟对血清ＳＯＤ和全血ＧＳＨ－Ｐｘ活性有明显抑制作用，且能增加血浆ＭＤＡ含量；“抗氟灵”可防止氟所致血清ＳＯＤ与全血ＧＳＨ－Ｐｘ活性下降，减少血浆ＭＤＡ含量，还能使氟损伤引起的ＳＯＤ与ＧＳＨ－Ｐｘ活性降低得以恢复。

To observe the effect of fluoride on the activities of SOD and GSH-Px and the content of MDA in blood and the antagonism to fluoride by 'Kangfuling ',40 healthy Wistar rats were randomly divided into five groups, respectively administrated fluoride solution and 'Kangfuling'. The experiment results revealed that fluoride could inhibit the activities of SOD and GSH-Px and increase the content of MDA,while 'Kangfuling'could resist the inhibition and revive the activities of SOD and GSH-Px which has been reduced by fiuoride.