煤尘对大鼠肺泡巨噬细胞分泌白细胞介素－1的影响

EFFECTS OF COAL DUSTS ON IL-1 SECRETION BY RAT'S AM

测定体外加煤尘后，不同时点大鼠肺泡巨噬细胞（ＡＭ）分泌白细胞介素－１（ＩＬ－１）的结果表明，煤尘组明显高于对照组，各煤组间，无烟煤组与肥煤组间差异不显著，而两组与贫煤组间有显著性差异。另外，随着煤尘浓度的增高，ＡＭ的ＩＬ－１分泌量也随之增加。我们认为ＩＬ－１可能在煤工尘肺发生发展中起重要作用。

The contents of interleukin-1 (IL-1) were assessed in the supernatant of coal dusts exposed rats' alveolar macrophages (AM). The results showed that the contents of IL-1 in coal dusts groups were significantly higher than those in the control group. The content of IL-1 in meager coal grorp was greatly lower than those in anthracite and fat coal groups. And a dose-dependent relationship existed between the concentration of dust and the content of IL-1. It is suggested that IL-1 might play an important role in the development of coal worker's pneumoconiosis.