狂犬病患者中和抗体检测的意义与发病关系探讨

Study on the significance of measuring the neutralizing antibody against rabies cases and the relationship between this antibody and the pathogenesis of rabies

对有确诊依据的３９例狂犬病患者进行抗狂犬病中和抗体检测。血清总阳性率为９７．４４％（３８／３９），但在前驱期和兴奋期仅为３５．９０％（１４／３９），麻痹期为９４．６０％（３５／３７）。脑脊液总阳性率为４０％（６／１５），在前驱期和兴奋期为３３．３３％（４／１２），麻痹期为７５％（３／４）。所有患者均未得到保护而发病。研究提示，这种抗体是病程后期的免疫应答，抗体效价也有一个由低到高的过程，可作为狂犬病的诊断依据之一。它的出现可能加速病程，即称作“早期死亡现象”。

Neutralizing antibody against rabies virus was demonstrated in the sera collected from 39 cases of corroborative rabid patients. The total sera positive rate was 97 . 44% ( 38 / 39 ) while only 35. 90 % ( 14/39) in prodromal period and exciting period , 94. 60% ( 35/37) in paralysis period . All patients were not protected and suffered from clinical rabies. This study indicated that the neutralizing antibody against rabies virus was an immune-response in the late course of rabies and had a course from low to high level. So the neutralizing antibody against rabies virus could be used as one of 'the diagnostic measures' . As the appereance of this antibody could accelerate the progress of the disease. we also called it ' the early death phenomenon '.