淋巴细胞功能抗原－1单抗治疗庆大霉素肾毒性的实验研究

Theprotectiveeffectofantibodytolymphocytefunction┐associatedantigen┐1onthepreventionofnephrotoxicityinducedbygentamicin

此实验结果表明ＣＤ１１ａ／ＣＤ１８单抗可明显减轻庆大霉素所致的肾脏病理损伤，从而使大鼠肾功能明显恢复。给药２４小时后治疗组血Ｃｒ值１３４．６±１５．１μｍｏｌ／Ｌ，明显低于ＣＤ３对照组（３６６．７±２８．３μｍｏｌ／Ｌ），（Ｐ＜０．０５）。病理检查示对照组均可见程度不同的肾小管坏死灶，而治疗组只有一例出现轻度肾小管坏死。提示细胞粘附分子在ＧＭ肾毒性的病理生理过程中可能起重要作用。

Amonoclonalantibody(McAb)againstlymphocytefunction-associatedantigen-1,ad-ministeredaftertheintraperitonealinjectionofgentamicinintherats,preventedbothfunctionalimpair-mentandhistologicchangesofrats′kidneys.Creatininevaluesinbloodmeasured24hafterthesecondinjectionofgentamicinwas134.6±15.1μmol/Lintheanti-lymphocytefunction-associatedantigen-1McAbtreatedanimalscomparedwith366.7±28.3μmol/LintheirrelevantMcAbtreatedgroup(P<0.05).TherewasmoderatetoseverenecrosisintheoutermedulawithfrequentmitosesinirrelevantMcAbtreatedkidneys.Necrosiswasmildwithfewmitosesonlyinonecaseofanti-lymphocytefunction-associatedantigen-1treatedanimals.Theseresultssuggestapossiblecriticalroleforleukocytesandad-hesionmoleculesinthepathophysiologyofthenephrotoxicityofgentamicinandmayhaveimportanttherapeuticimplications.