摘要
本文研究人类精液中幼稚生殖细胞的微核率和男性不育的关系。在31例病人中,11例为无精症或多精症患者,其精液缺乏幼稚生殖细胞而未能进行微核测定。在其余的20例中,微核率最高可达122‰,最低为16‰。其中9例的微核率与对照组相比有显著升高,高微核率往往还伴随有减数分裂不分离以及出现高比例的二倍体及四倍体精子。还讨论了生殖细胞微核率增高作为不育症的一个可能病因以及微核测定的临床使用价值。
The immature germ cells of human semen were used for study of the relation between chromosomal damage and male infertility. Semen samples arc collected from 31 infertile men and 5 fertile donors. The results show that the micro-nucleus (MN) frequency of 9 cases arc statistically higher than that of control group. The highest MN frequency is 122‰ and the lowest is 16‰ in 20 cases. In other 11 cases which are azoospermia or poiyspermia, we have not observed the MN for lack of immature germ cell in the semen. The high MN frequency invariably accompanied the non-disjunction of meiosis and high frequency of diploid and tetraploid spermatids or sperm. Our results also indicate that the increase of micronuclei is a possible factor of male infertility. The use of MN as an indicator of genotoxic exposure of man is also discussed.
关键词
不育症
精液生殖细胞
微核
男性
Infertility, Immature germ cell in semen, Micronucleus
