朱砂溶出的体外研究

Investigation on dissolution of cinnabar In vitro

目的:研究胃肠道中存在的各种化学因素(酸度,蛋白质,氨基酸,离子强度,Na2S)对朱砂溶出的影响。方法:分别使用紫外可见分光光度仪、纳米粒度仪、质谱仪对朱砂在不同化学体系溶出液中汞的浓度、溶出液的粒度分布以及溶出物的组成进行分析。结果:朱砂主要不以纳米颗粒形式溶出,含巯基的氨基酸对朱砂的促溶作用有限,而Na2S对朱砂中汞溶出量的影响显著高于其他,pH对朱砂中汞的溶出量也有较大的影响。结论:推测朱砂在胃肠道中的溶出物可能主要为汞的各种含硫配合物。

Objective： To study effects of different chemical factors in gastrointestinal tract, i.e. pH, protein, amino acid, ionic strength, Na2S, on the dissolution of cinnabar. Method： The content of total mercury in various dissolution of cinnabar were analyzed by UV/VIS Spectrophotometer. The particle distributions in dissolution of cinnabar were measured by Laser Particle Size Analyzer. The constituents of dissoluble substance of cinnabar in presence of Na2S were determined using ESI-MS. Result： The solubility of cinnabar could be increased significantly in the presence of Na2 S/S^0, and strong acidic pH, respectively. While the influence of thiol amino acid on promoting dissolution remains relatively low. Cinnabar didn＇t dissolve mainly in the form of nanoparticle. Conclusion： We postulated that cinnabar could be dissolved in various forms of mercury complexes containing sulphur.