参附注射液对肝胆外科患者术后康复的影响

Effect of Shenfu injection in postoperative recovery after abdominal surgery

目的:观察参附注射液对肝胆外科患者术后康复的影响。方法:150例手术患者随机分为对照组和参附注射液组(SF组)各75例,观察两组患者肛门排气时间、切口愈合情况、血常规、凝血功能、肝功能、组织修复相关因子、免疫功能及血液流变指标的变化。结果:SF组患者平均肛门排气时间较对照组显著缩短(P<0.05);手术前后SF组与对照组比较,血常规、凝血功能及肝功能指标无显著差异;术后SF组全血黏度(1.s-1,22.s-1,200.s-1),血液还原黏度,纤维蛋白浓度较对照组降低。术后SF组IgG,IgA较对照组升高;对照组术后IgG,CD4+/CD8+较术前降低;术后所有病例SOD明显降低,SF组降幅小于对照组(P<0.05);对照组术后MDA明显升高(P<0.05)。术后对照组血液还原黏度,纤维蛋白浓度,全血黏度较术前升高;SF组术前术后血液流变指标比较无显著差异。结论:参附注射液可提高手术患者术后免疫功能,减少组织的损伤,促进血液循环,有助于术后康复。

Objective： To investigate the effect of Shenfu injection （SF） in postoperative recovery after abdominal surgery. Method： 150 patients were randomly divided into control group （75） and SF group （75）. The efficacy were evaluated with the time of passage of gas by anus, information of wound healing, blood routine, blood coagulaton function, liver function. Changes recovery factor, immune index and bemorbeological index were detected too. Result： The time of passage of gas by anus in SF group was significantly shorter than that in control group. Blood routine, blood coagulaton function, liver function showed no significant difference in the two group of preoperative and postoperative. Whole blood viscosity, blood reduced viscosity and plasma fibrinogen viscosity in SF group were significantly lower than that in control group after operation. IgG and IgA in SF group was significantly higher than that in control group after operation. IgG and CD4 ^＋//CD8^ ＋ in control group was significantly higher after operation than that in before operation. Among tissue damage plerosis correlation factor, the blood levels of superoxide dismutase （SOD） in SF group and control group is significantly lower than that in preoperation （P 〈0. 05）, SOD in SF group was significandy higher than that in control group after operation. The blood levels of malondiaidehyde （MDA） in SF group and control group is significandy higher than that in preoperation （ P 〈 0. 05）. MDA in SF group was significantly lower than that in control group after operation. Whole blood viscosity, blood reduced viscosity and plasma fibrinogen viscosity in control group after operation were significandy higher than that before operation. Conclusion： SF can stimulate the immune system and reduce the blood viscosity. It is contribute to the patients＇ rehabilitation.