构棘化学成分研究

Studies on chemical constituents from roots of Cudrania cochinchinensis

目的:研究桑科柘属植物构棘Cudrania cochinchinensis干燥根的化学成分。方法:利用各种硅胶、聚酰胺柱色谱技术进行分离纯化,根据NMR,MS等波谱分析和理化性质鉴定其化学结构。结果:从构棘95%乙醇提取物的醋酸乙酯部分分离得到6个黄酮类化合物。分别为3,5,7,4′-四羟基黄酮-7-O-(6″-乙酰基)-葡萄糖苷(1),3,5,7,4′-四羟基黄酮-7-O-葡萄糖苷(2),6-异戊烯基-5,7,2′,4′-四羟基二氢黄酮(3),6-异戊烯基-5,7,4′-三羟基异黄酮(4),1,3,5,6-四羟基酮(5),2,4,3′,5′-四羟基二苯乙烯(6)。结论:化合物1为首次从本属植物中分得,4,5为首次从本植物中分得。

Objective： To study the chemical constituents from the roots of Cudrania cochinchinensis. Method： The chemical constituents of C. cochinchinensis were isolated and purified by silica gel, polyamide column chromatography, Their structures were identhqed on the basis of spectroscopic data. Result： Six compounds were isolated and identified. Their structures were established as 3, 5, 7, 4″-tetrahydroxyflavanone-7-O-（6″-acetyl）-glucoside （1）, 3, 5, 7, 4＇-tetra hydroxyflavanone-7-O-glucoside （2）, 2＇, 4＇, 5, 7-tetrahydroxy-6-prenyldihydroflavanone （3）, 5, 7, 4＇-trihysdroxy-6-prenylisoflavanonc （4）, 1, 3, 5, 6-tetrahydroxyxanthone （5）, stilbene-2, 4, 3＇, 5＇-tetraol （6）. Conclusion： Compound 1 was isolated from this genus, while compounds 4 and 5 were isolated from this plant for the first time.