摘要
利用精细加工聚焦离子柬技术在氮化硅绝缘晶体上研制了形状不同的微纳米沟道，并结合非接触模式原子力显微技术观察了缓冲液和DNA溶液在沟道内运动的各自形貌。对沟道内溶液的形貌特性，尤其是一种表面有纳米沟槽的DNA溶液形貌进行了分析讨论。微纳孔道与原子力显微镜成像技术相结合，有助于更多地理解生物单分子动力学和静力学等方面的性质。
A sort of open fluidic channels with rectangle cross section （lμm in width and 150nm in depth） is fabricated by the art-of-the-state milling techniques of Focused-Ion-Beam. The morphologies of pure buffer solution and DNA-contained solution in the open channels have been explored with a non-contact Atomic Force Microscopy, respectively. The movements of DNA molecules confined in the open channels, especially, the profile of a nanotreneh （15nm deep and 141xm long） emerged on the DNA solution surface, are discussed. Associating with Atomic Force Microscopy technologies, these scale miero-/nano-struetured open fluidic channels would be useful for studying single biomoleeules statics as well as the dynamics.
基金
深圳大学科研启动基金资助项目（编号：4wkg）
