静脉应用胺碘酮治疗器质性心脏病伴快室率心房颤动的临床疗效

The Efficacy with Intravenous Amiodarone in Treatment of Fast Atrial Fibrillation (AF) with Organic Heart Disease

目的观察静脉应用胺碘酮治疗器质性心脏病伴快室率永久性房颤患者的临床疗效及安全性。方法41例器质性心脏病合并房颤患者:男26例,女15例,年龄61.4±12.1(49～77岁),房颤病史半年以上,入院时心室率为151±19.3(134～179)次/分。给予静脉负荷量胺碘酮(150～300mg)后,继之以1mg/小时静脉滴注6小时,后以0.5mg/分持续滴注42小时。结果41例患者用药后1h、2h、6h、24h、48h心室率分划为121.3±11.7,111.5±9.3,94.7±8.7,88.4±8.6,84.2±7.3较用药前明显下降(P<0.01),心功能明显好转,在治疗过程中,2例出现血压下降,1例出现长R-R间期,经减量给药后血压稳定,长R-R间期消失。结论静脉应用胺碘硐治疗器质性心脏病伴快室率房颤患者有效且安全。

Objective To observe the efficacy and security with intravenous amiodarone for perpetual atrial fibrillation （AF） and fast ventricular rate with organic heart disease. Methods Forty one patients of AF with organic heart disease, The time of AF beyond half year, The ventricular rate was 151±19.3 （134-179）bpm. They were treated with loaded intravenous amiodarone （150-300mg）, and dripped lmg/min for 6 hours, Then 0.5mg/ min for 42 hours observed the efficacy of reduced ventricular rate and side effects. Results The ventricular rate was 121.3±11.7, 111.5±9.3, 94.7±8.7, 88.4±8.6, 84.2±7.3bpm at 1, 2, 6, 24, 48h respectively ventricular rate was reduced significantly than pretreated （151±19.3bpm, P〈0.01） Blood pressure was dropped in two patients, long RR intermittent in one patient, Blood pressure was steadied, Long RR intermittent was disappeared after reduce. Conclusions The results showed it was effective and safe with intravenons amiedarone in treatment of AF and fast ventricular rate with organic heart disease.