低分子肝素钙、辛伐他汀联合治疗不稳定型心绞痛疗效观察

Clinical observation of lowmolecular heparin calcium combined with simvastatin on unstable angina pectoris

目的观察低分子肝素钙(尤尼舒)、辛伐他汀联合治疗不稳定型心绞痛的治疗疗效。方法96例不稳定型心绞痛病人随机分成治疗组和对照组。两组均进行严格内科药物治疗,治疗组在药物治疗基础上用低分子肝素钙5000u,皮下注射,每日2次,疗程为1周,同时口服辛伐他汀20mg,每晚1次,长期服用。观察两组心绞痛发作及心电图变化。结果治疗组显效率53.3%,总有效率95%,对照组显效率27.8%,总有效率72%。两组比较显效率及总有效率有显著差异(P<0.05),随访三个月,对照组有3例发生心肌梗死,治疗组无一例发生心肌梗死,无明显不良反应。结论低分子肝素钙、辛伐他汀联合应用,能有效减少心绞痛发作,可降低心肌梗死发生率。

Objective To evaluate the efficiency and safety of simvastatin combined with Lowmolecular heparin calcium on unstable angina pectoris COAP）. Methods Ninty-six patients with UAP were divided randomly into treatment group and control group. The patients in control group were treated with routinely; The patients in treatment group were added with lowmolecular hepafin calcium and simvastatin besides theabove medications. Lowmolecular heparin calcium： 5000u subcutaneously b.i.d for a week, Simvastatin： 20mg Take orally Q.N. The ECG, episode times and strength were detected. Results The treatment group： the marked effective rate was 53.3% and total effective rate was 95%; the control group： the marked effective rate was 27.8% and total effective rate was 72%. There was significant difference between two groups （p〈0.05）. Makes a follow-up visit for three months, there were 3 cases of myocardial infarction in the control group. Condusions Lowmoleeular heparin calcium combined with simvastatin is helpful to reduce the times of angina pectoris and to Lower the occurrence rate of myocardial infarction.