摘要
泛素一蛋白酶体途径（ubiquitin—proteasome pathway,UPP）是一种高效的蛋白分解途径，其生物学作用非常广泛，该途径的异常与诸多疾病如遗传性疾病、炎症、自身免疫性疾病及肿瘤等有密切关系。泛素-蛋白酶体自被发现以来，受到了极大的关注和重视。在2004年，以色列科学家阿龙．切哈诺沃、阿夫拉姆．赫尔什科和美国科学家欧文．罗斯因发现了泛素对蛋白质降解的调节，获得了诺贝尔化学奖。近期已注意到UPP在癌肿治疗中的作用，并已开展了以泛素-蛋白酶体为靶的治疗试验。目前对UPP的研究已经取得了很大的进展。本文就UPP与疾病和治疗的关系进行综述。
出处
《海南医学》
CAS
2007年第3期141-142,152,共3页
Hainan Medical Journal
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