摘要
①目的探讨异氰酸酯的无光气制备方法。②方法对Ｃｕｒｔｉｕｓ重排反应制备异氰酸酯的方法进行改进。于７０～１００℃的叠氮钠与甲苯的混合物中滴加乙酰氯或丙酰氯，３０ｍｉｎ加完后再维持反应３０ｍｉｎ，精馏收集３８～３９℃馏份（异氰酸甲酯）或６０～６１℃馏份（异氰酸乙酯）。③结果产率７７％～８２％．④结论本方法无需光气，工艺简单，产率较高。
Objective To search for a phosgene free method for preparing organic isocyanates with a high yield. Method The modified classic method of preparing organic isocyanates by Curtius rearrangement was used. Acetyl chloride or propionyl chloride was dropped into the mixture of sodium azide in a period of 30 minutes at 70￣100℃. After another 30 minutes, the resulting methyl isocyanate or ethyl isocyanate was obtained by ways of rectification at 38￣39℃ and 60￣61℃, respectively. Result High yield of 77%￣82% was obtained by the modified classic method. Conclusion The modified classic method with its high yield is a one stage , non-explosive, phosgene free method for the preparation of organic isocyanates.
出处
《青岛医学院学报》
1996年第3期207-208,共2页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省教委科研基金
关键词
Curtius重排
制备
异氰酸酯
curtius rearrangement
preparation
organic isocyanates
improvement
