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几种免疫细胞在感染HIV-1过程中的作用 被引量：4

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摘要 随着免疫学的发展,人们发现艾滋病病毒Ⅰ型(HIV-1)感染及其疾病进展与机体内一些细胞的免疫功能有关。CD4+CD2+5调节性T细胞(Tr)在机体感染免疫中具有重要作用,在人类HIV-1感染中CD4+CD2+5T细胞能控制机体CD4+和CD8+T细胞的特异性抗HIV-1免疫应答,并且与HIV-1感染状态有关。在多种疾病中都发现Th1/Th2的异常转化。目前多数研究结果表明:HIV-1感染也会造成Th2的极化,并最终造成CD4+T细胞功能的缺失。在机体抗HIV-1感染中,树突状细胞(DC)具有双重作用,DC在HIV-1感染中的这种双重作用导致机体内DC数量减少及功能削弱。NK细胞是对抗病毒感染的第一道防线,慢性HIV-1感染会引起NK细胞群的异常。有学者报道CD5+6CD1+6CD3-CD4+CCR5+/CXCR4+的NK细胞可被HIV-1感染,使感染者天然免疫功能低下。虽然上述这些细胞在HIV-1感染中都有各自的功能,但是作为免疫系统网络整体而言,它们功能变化导致的HIV-1感染性疾病的进展是这些细胞相互作用、相互调节、共同作用的结果。
作者 李莉 曹韵贞
机构地区 中国医学科学院中国协和医科大学艾滋病研究中心
出处 《中国艾滋病性病》 CAS 2007年第1期82-86,共5页 Chinese Journal of Aids & STD
关键词 艾滋病病毒Ⅰ型 免疫细胞 CD4^+CD25^+调节性T细胞 树突状细胞 NK细胞
分类号 R373.9 [医药卫生—病原生物学]
  • 相关文献

参考文献42

  • 1Iuestone JA,Abbas AK.Natural versus adaptive regulatory T cells[J].Nat Rev Immunol,2003,3(3):253-257.
  • 2Okazaki T,iwai Y,Honjo T.New regulatory co-receptors:inducible co-stimulator PD-1.[J].Curt Opin lmmunol,2002,14(6):779 -782.
  • 3Walker MR,Kasprowicz DJ,Ziegler SF.Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4^+ CD25^+Tcells[J].J Clin Invest,2003,112(9):1437-1443.
  • 4Hori S,Nomura T,Sakaguchi S.Control of regulatory T cells development by the transcription factor FoxP3[J].Science,2003,299 (5609):1057-1061.
  • 5Zheng SG,Wang JH,Gray JD,et al.Natural and induced CD4^+ CD25^+cells educate CD4^+ CD25^+ cells to develop suppressive activity:the role of IL-2,TGF-beta,and IL-10[J].J Immunol,2004,172 (9):5213 -5221.
  • 6Vieira PL,Christensen JR,O Garra A,et al.IL-10-secreting regulatory T cells do not express FoxP3 but have comparable regulatory function to naturally occurring CD4^+ CD25^+ regulatory T cells[J].J Immunol,2004,172(10):5986-5993.
  • 7Belkaid Y.The role of CD4^+ CD25^+ regulatory T cells in Leishmania infection[J].Expert Opin Biol Ther,2003,3(6):875 -885.
  • 8Long TT,Nakazawa S,Onizuka S,et al.Influence of CD4^+ CD25^+ T cells on Plasmodium berghei Nk65 infection in BALB/c mice[J].Int J Parasitol,2003,33(2):175-183.
  • 9Einar MA,Jakob M,Walter JM,et al.Human CD4^+ CD25^+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens[J].Journal Of Virology,2004,78(5):2454-2459.
  • 10Jonuleit H,Schmitt E.The regulatory T cell family:distinct subsets and their interrelations[J].J Immunol,2003,171 (12):6323 -6327.

二级参考文献27

  • 1Levy JA. The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol, 2001, 22(6) : 312-316.
  • 2Diefenbach A, Raulet D. Strategies for target cell recognition by natural killer cells. Immunological Reviews, 2001, 181: 170-184.
  • 3Miller J. The biology of natural killer cells in cancer, infection and pregnancy. Experimental Hematology, 2001, 29: 1157-1168.
  • 4Fortis C, Tasca S, Capiluppi B, et al. Natural killer cell function in HIV-1 infected patients. J Biol Regul Homeost Agents, 2002, 16( 1 ):30-32.
  • 5de Souza MS, Karnasuta C, Brown AE, et al. A comparative study of the impact of HIV infection on natural killer cell numbex and function in Thais and North Americans. AIDS Res Hum Retroviruses, 2000, 16(11): 1061-1066.
  • 6Doherty DG, Norris S, Madrigal-Estebas L, et al. The human liver contains multiple populations of NK cells, T cells, and CD3+ CD56 + nutural T cells with distinct cytotoxic activities and TH 1, TH2, and TH0 cytokine secretion patterns. J Immunol, 1999, 163: 2314-2321.
  • 7Franitza S, Grabovsky V, Wald O, et al. Differential usage of VLA-4 and CXCR4 by CD3+ CD56+ NKT cells and CD56+ CD16+ NK cells regulates their interaction with endothelial cells. Eur J Immunol, 2004,34: 1333-1341.
  • 8Biron CA, Brossay L. NK cells and NKT cells in innate defense against viral infections. Current opinion in immunology, 2001, 13: 458-464.
  • 9Unutmaz D. NKT eeUs and HIV infection. Microbes Infect, 2003, 5(11): 1041-1047.
  • 10van der Vliet HJ, yon Blomberg BM, Hazenberg MD, et al. Selective decrease in circulating V alpha 24 + V beta 11 + NKT cells during HIV type 1 infection. J Immunol, 2002, 168(3) : 1490-1495.

共引文献47

同被引文献31

引证文献4

二级引证文献8

中国艾滋病性病
2007年 第1期

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