长托宁联合力月西应用于小儿术前给药的临床观察

Clinical observation of penehyclidine hydrochloride and midazolam as premedication in chidren

目的观察长托宁联合力月西应用于小儿术前用药对镇静、情绪、心率、血压及呼吸道分泌物的影响。方法4-10岁泌尿外科患儿40例，ASAⅠ级，随机分为两组，A组20例肌注阿托品0．02mg／kg＋鲁米那钠2mg／kg；B组20例肌注长托宁0．02mg／kg＋力月西0．1mg／kg，分别记录基础值、入室、诱导、手术开始、术毕各时点的平均动脉压（MAP）、心率（HR）、脉搏氧饱和度（SpO2）；观察镇静、情绪状态、与父母分离和静脉穿刺时的行为变化及在麻醉诱导时面红、口干程度、手术结束时有较多分泌物的病例数。结果长托宁联合力月西应用对患儿的心率和血压影响轻微，而抑制腺体分泌的作用较强且还具有一定的镇静和抗焦虑作用。结论长托宁联合力月西应用于小儿术前效果满意，是一种较好的小儿麻醉前用药配伍组合。

Objective To observe the clinical effect of sedation, emotional state, heart rate, blood pressure and respiratory tract secretion substance in penehyclidine hydrochloride and midazolam as premedication in chidren. Methods Forty 4 - 10 years children ASA I uninary surgery were randomly divided into two groups . Each group was twenty cases . A group with atropine 0. 02 mg/kg and phenobarbital sodium 2 mg/kg im , B group with penehyclidine hydrochloride 0.02 mg/kg and midazolam 0. 1 mg/kg im. MAP,HR and SpO2 were recorded in base , entering operationroom, anesthesia induction , pro - operation and post - operation. Seduation , emotional state , behaviour at separation from parents and venepucture were observed . Cases of flushing in anesthesia induction and dry of mouth and respiratory tract secretion substance were counted. Results The effect on HR and blood pressure were little ,but on restrained glandular organ secretony were better and the effect on sedationand and antianxiety were better also of penehyclidine hydrochloride and midazolam as premedication in chidren. Conclusion The effectiveness is satisfactory of penehyclidine hydrochloride and midazolam＇as premedication in chidren , so it is a comparatively ideal premedication.