重型肝炎患者人工肝支持系统治疗时血清肿瘤坏死因子-α、白细胞介素-2和白细胞介素-10水平的变化

Changes in the concentrations of TNF-α,IL-2 and IL-10 by artificial liver support system in patients with severe hepatitis

目的研究重型肝炎患者人工肝支持系统(ALSS)治疗前后外周血中肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)和白细胞介素-10(IL-10)水平的变化。方法应用血浆置换技术治疗重型肝炎患者37例,采用ELISA法于每次治疗前后检测TNF-α、IL-2的IL-10的水平,并观察其动态变化情况。结果重型肝炎患者血清TNF-α水平明显高于对照组,IL-2水平明显低于对照组,ALSS治疗后TNF-α水平下降,IL-2和IL-10则呈逐渐上升趋势。结论ALSS治疗可降低重型肝炎患者TNF-α的水平,升高IL-2和IL-10的水平,抑制炎性介质的产生,减轻免疫反应对肝细胞的损伤,提高重型肝炎患者的存活率。

Objeetive To explore the effect of artificial liver support system（ALSS） on the concentrations of TNF-α, IL-2 and IL-10 in patients with severe hepatitis. Methods Thlrty-seven patients suffering from severe hepatitis were treated with plasmapheresis. The concentrations of TNF-α, IL-2, IL-10 and liver function were detected before and after therapy. Results The liver function was significantly im- proved after plasmapheresis.-The concentration of TNF-α decreased significantly, and the concentrations of IL-10 and IL-2 increased. Conclusion The ALSS treatment can effectively decrease the concentrations of TNF-α and increase the concentrations of IL-10 and IL-2 in the circulation, and it is valuable to improve the survival rate.