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胰岛素增敏剂对初诊2型糖尿病患者血清C-反应蛋白的影响 被引量:2

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摘要 目的比较罗格列酮与二甲双胍对初诊2型糖尿病患者血清C-反应蛋白(CRP)的影响,探讨胰岛素增敏剂对2型糖尿病患者慢性炎症的治疗价值。方法将50名初诊超重或肥胖的2型糖尿病患者随机分为罗格列酮组(治疗组,22例)与二甲双胍组(对照组,28例)。治疗组患者每天空腹口服罗格列酮4mg,对照组患者每日早晚餐后口服二甲双胍850mg,疗程为12周。结果治疗12周后,两组患者的空腹血糖、餐后2小时血糖、糖化血红蛋白、血清C-反应蛋白(CRP)与治疗前比较均有明显下降(P<0.05);与二甲双胍组比较,罗格列酮组患者的血清C-反应蛋白(CRP)下降更明显(P<0.05);而二甲双胍组体重指数(BMI)与治疗前比较下降更明显(P<0.05)。结论对超重或肥胖的2型糖尿病患者罗格列酮与二甲双胍均能较好地控制血糖水平,而罗格列酮在有效降糖的同时还能明显降低血清C-反应蛋白(CRP)水平,提示其有更明显的抗炎作用,可能对糖尿病患者大血管并发症的发生具有干预治疗作用。
出处 《临床内科杂志》 CAS 2007年第2期128-129,共2页 Journal of Clinical Internal Medicine
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