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多囊卵巢综合征胰岛素抵抗与子宫内膜病变 被引量：6

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摘要 近年临床资料分析,胰岛素抵抗与多囊卵巢综合征(PCOS)患者子宫内膜增生存在很高的一致性,且PCOS患者患子宫内膜癌的几率高。近年研究发现,胰岛素除有促代谢的作用外,其促细胞生长、增生的作用越来越受到重视,且与多种肿瘤的发生机制有关。PCOS胰岛素抵抗与子宫内膜病变的机制可从几方面分析:胰岛素抵抗影响体内性激素水平;胰岛素本身促进细胞增殖分化;胰岛素抵抗影响体内胰岛素样生长因子的水平;胰岛素抵抗与基因表达异常的细胞协同促进细胞增生,加速了细胞恶变。
作者 杨振艳 韩玉崑
机构地区 天津医科大学总医院妇产科
出处 《国外医学（妇产科学分册）》 2007年第1期43-46,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 多囊卵巢综合征 胰岛素抵抗 高胰岛素血症 子宫内膜病变
分类号 R711.75 [医药卫生—妇产科学]
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参考文献20

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同被引文献56

  • 1李国华,黄薇.二甲双胍在多囊卵巢综合征的应用[J].实用妇产科杂志,2005,21(9):534-537. 被引量：34
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  • 3Talbi S, Hamilton AE, Vo KC, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women [ J ]. Endocrinology,2006,147 : 1097-1121.
  • 4Giudice LC. Endometrium in PCOS:implantation and predisition to endocrine CA [ J ]. Best Pract Res Clin Endocrinol Metab,2006,20:235-244.
  • 5Taylor AH, Guzail M, Wahab M, et al. Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the nomal human endometrium through the menstrum cycle [ J ]. Histochem Cell Biol, 2005,123 : 463-474.
  • 6Tschugguel W, Dietrich W, Zhegu Z, et al. Differential reg- ulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultred human uterine artery endothelial cells [ J]. J Clin Endocrinol Metab, 2003,88 : 2281- 2287.
  • 7Krikun G, Schatz F, Taylor R, et al. Endometrial endothelial cell steroid receptor expression and steroid effects on gene expression [ J ]. J Clin Endocriol Metab, 2005,90 : 1812-1818.
  • 8Villavicencio A, Bacallao K, Avellaira C, et al. Androgen and estrogen receptors and co-regulators levels in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia [ J ]. Gynecol Oncol, 2006,98 : 307-314.
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  • 10Jakubowicz DJ, Essah PA, Seppala AJ. Polycystic ovary syndrome during first trimester of pregnancy [ J ]. Clin En- docrinol Metab ,2004,89:833-839.

引证文献6

二级引证文献35

国外医学（妇产科学分册）
2007年 第1期

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