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妊娠高血压综合征胎盘组织中细胞因子基因的表达 被引量：1

Expression of cytokine-associated genes in placenta from patients with pregnancy-induced hypertension
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摘要 目的:研究细胞因子及相关基因在妊娠高血压综合征(简称妊高征)胎盘和正常胎盘组织中的表达差异。方法:以包含220余种人类细胞因子相关基因cDNA片段的基因芯片,检测严格配伍的妊高征和正常胎盘组织中基因表达谱的差异。结果:除白细胞介素和肿瘤坏死因子(受体)基因超家族外,39种细胞因子和15种细胞因子受体基因在妊高征和正常胎盘组织中的表达水平存在2倍以上的差距,且绝大多数表现为在妊高征胎盘组织中的表达增高。结论:胎盘中细胞因子相关基因的强烈表达可能与妊高征的病理发生关系密切。 Objective： To study the difference of cytokine - associated genes expression in placenta from normal parturients and patients with pregnancy - induced hypertension （PIH） . Methods： The mRNA content of cytokine - associated genes in placenta was assayed by a complementary DNA segment representing over 220 cytokine - associated genes. Results： Over twice difference of the expression of 39 cytokines and 15 cytokine receptor genes, with interleukin and tumor necrosis factor （receptor） gene super family not included, was found between placental tissues from normal parturients and those from patients with PIHS. And most of these genes were up - regulated in placenta with PIHS. Conclusion： The up - regulation of cytokine - associated genes expression in placenta might be closely related to the pathogenesis of PIHS.
作者 钟文筠 周君桂 庞战军
机构地区 深圳市布吉人民医院 广州第一军医大学南方医院
出处 《中国妇幼保健》 CAS 北大核心 2007年第6期818-822,共5页 Maternal and Child Health Care of China
关键词 基因芯片 细胞因子 妊娠高血压综合征 胎盘 Gene segment Cytokine Pregnancy- induced hypertension Placenta
分类号 R714.246 [医药卫生—妇产科学]
  • 相关文献

参考文献17

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二级参考文献8

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同被引文献15

  • 1胡泽平,王邦宁.肝细胞生长因子在内皮细胞和高血压中的研究进展[J].心血管病学进展,2005,26(6):595-598. 被引量：3
  • 2欧阳珊,乔福元.妊娠期高血压疾病胎盘肝细胞生长因子表达与滋养细胞凋亡[J].中华围产医学杂志,2006,9(4):233-235. 被引量：4
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  • 7Wang X, Zhou Y, Kim HP et al. Hepatocyte growth factor protects a- gainst hypoxia/reoxygenation -induced apoptosis in endothelial cells [J]. J Biol Chem, 2004, 279 (7) : 5237.
  • 8Bergkamen HS, Brenner D, Krueger A et al. Hepatocyte growth factor induces Mcl - 1 in primary human hepatocytes and inhibits CD95 - me- diated apoptosis via Akt [J]. Hepatology, 2004, 39 (3) : 645.
  • 9Dash PR, Cartwright JE, Baker PN et al. Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP - dependent mechanism and independently of caspase - 3 nitrosylation [ J ]. Exp Cell Res_ 2003_ 287 (2): 314.
  • 10Dash PR, Cartwright JE, Whitely GS. Nitric oxide inhibits polyamine - induced apoptosis in the human extravillous trophoblast cell line SGHPL -4 [J]. Hum Reprod, 2003, 18 (5): 959.

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中国妇幼保健
2007年 第6期

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