运动对血管内皮生长因子的影响及其机制

Effect and mechanism of exercise on vascular endothelial growth factor

目的:通过了解运动训练与血管内皮生长因子的相关性,探讨运动训练对血管内皮功能的影响。资料来源:应用计算机检索Pubmed1995-01/2005-12有关血管内皮生长因子方面的文献,检索词“VEGF,exercise”,限定文章语言种类为English。并检索中文期刊全文数据库1995-01/2005-12有关血管内皮生长因子方面的文献,检索词“血管内皮生长因子,运动”,限定文章语言种类为中文。资料选择:对资料进行初审,选取包括运动及血管内皮生长因子的相关文献,开始查找全文。纳入标准:有关运动及血管内皮功能的研究。排除标准:重复研究或资料陈旧。资料提炼:共检索到关于运动及血管内皮生长因子的文献202篇,中文46篇,英文156篇,24篇文献符合纳入标准,其中急性运动对血管生长因子影响的文献7篇;运动训练对血管内皮生长因子影响的文献7篇,其他文献为运动相关文献或有关免疫、缺血缺氧及一氧化氮合酶等对血管内皮的影响。资料综合:①血管内皮生长因子可以在很多正常人和动物组织中表达,但表达水平较低。其具有增加微血管的通透性、与特异性的血管内皮细胞受体结合、刺激血管内皮细胞分泌一氧化氮及保护损伤神经组织等作用。②运动对血管内皮细胞的影响机制可能为:缺血缺氧引起一些促血管生成的因子如血管内皮生长因子上调。各种原因引起的免疫性复合物增多、活化补体、细胞肽(白细胞介素、肿瘤坏死因子)产生过多和异种蛋白增多等均可引起内皮细胞损伤。血管内皮生长因子的作用与一氧化氮表达有关,作为信息分子的一氧化氮与血管内皮生长因子的表达互为正反馈调节。结论:无论是急性运动还是运动训练都对心血管功能产生一定的影响,因缺氧缺血或免疫因子的激活等因素的影响,急性运动或运动训练后血管内皮生长因子显著增加,这有利于血管内皮修复或代偿性的侧支循环。

OBJECTIVE： To understand the correlation between exercise and vascular endothelial growth factor （VEGF）, and explore the effect of exercise on VEGF. DATA SOURCES： A computar-based search was conducted in Pubmed for literatures related to VEGF published between January 1995 and December 2005 with the key words of ＂VEGF, exercise＂, and the language was limited to English. Meanwhile, CNKI was looked for relevant articles published from January 1995 to December 2005 with the key words of ＂VEGF, exercise＂, and the language was limited to Chinese. STUDY SELECTION： Data ware checked in the first trial, and literatures related to exercise and VEGF ware selected and looked for the full text, Inclusion criteria： Research related to exercise and VEGF. Exclusion criteria： Repetitive studies or old data. DATA EXTRACTION： A total of 202 literatures related to VEGF and exercise ware retrieved, including 46 Chinese articles, 156 English articles, and 24 literatures ware in accordance with the inclusion criteria, of which 7 literatures on the effect of acute exercise on VEGF, 7 articles ware about the effect of e^ercise on VEGF, and others ware about the effects of exercise, immune, ischemia, hypoxia and nitriC oxide synthase on VEGF. DATA SYNTHESIS： ① Theirs ware lower expressions of VEGF in tissues of normal people and animals, which could increase the microvascular permeability, combine with specific VEGF receptor, stimulate the secretion of nitric oxide and protect injured neural tissues etc. ② The action mechanism of exercise on VEGF might be： the up-regulation of ischemia hypoxia induced vascular factors such as VEGF. Increased immune compounds, activated compliment, cellular peptide （interleukin, tumor necrosis factor） and heterologous protein would cause the injury of endothelial cells. The effect of VEGF was related to the expression of nitric oxide. As the informational molecule, theexpmssions of nitric oxide and VEGF could be the positive feedback regulation of each other. CONCLUSION： Both acute exercise and exercise have certain effects on the cardiovascular function, which may be significantly increased owing to the effects of hypoxia ischemia or the activation of immune factors, and these will contribute to the restoration of vascular endothelium as wall as benefit the compensate bypass circuit.