血管内皮生长因子及其受体在门静脉高压性胃病中的表达及其意义

Expression of vascular endothelial growth factor and its receptor in portal hypertensive gastropathy.

目的 探讨血管内皮生长因子（VEGF）及其受体FLT-1、FLK-1mRNA在门静脉高压性胃病（PHG）中的作用。方法 采用逆转录聚合酶链反应（RT-PER）对44例肝硬化门静脉高压症患者PHG动态变化过程中病变部位的VEGF、FLT-1及FLK-1mRNA的表达进行检测。结果 轻度胃病组VEGF、FLT-1、FLK-1mRNA的表达量分别为（2．28±0．33）、（0．59±0．17）和（0.56±0．14），与无胃病组及正常对照组比较差异均有显著性（均P〈0．01）；重度胃病组VEGF、FLT-1、FLK-1mRNA分别为（3．48±1．02）、（0．68±0．20）和（0.71±0．18），与轻度胃病组、无胃病组及正常对照组比较差异均有显著性（均P〈0．01）。结论 VEGF及其受体FLT-1、FLK-1过度表达是胃病胃黏膜损害的重要因素之一。

Objective To study the role of vascular endothelial growth factor （ VEGF ） and its receptor FLT-1,FLK-1 mRNA in the development of portal hypertensive gastropathy （PHG）. Methods The expression of VEGF and its receptor FLT-1, FLK-1 mRNA in 44 patients with PHG were analyzed by reverse transcription-polymerase chain reaction （RT-PCR）. Results VEGF and its receptor FLT-1, FLK-1 mRNA were all detected in the gastric mucosa, with higher level in the moderate PHG than the patients without PHG and the normal controls [ （ 2.28 ± 0.33 ）, （ 0.59 ± 0. 17 ）, （ 0.56 ± 0.14 ） P 〈 0.01 respectively]. The expression of VEGF and its receptor FLT-1, FLK-1 mRNA were higher in the severe PHG than the moderate PHG and the patients without PHG [ （3.48 ± 1.02 ） , （0.68 ± 0.20 ）, （0.71 ± 0.18 ） P 〈 0.01 respectively ]. Conclusion The expression of VEGF and its receptor FLT-1 ,FLK-1 mRNA is up-regulated in the portal hypertensive gastric mucosa,which are one of the important factors in the development of PHG.