电离辐射对小鼠血和肝细胞生物氧化酶活性的影响

Effect of ionizing radiation on bio-oxidase activities in cytoplasm of mouse blood and liver cells

报道了经不同剂量（３，６，９和１２Ｇｖ）照射后小鼠血液和肝细胞浆内生物氧化酶活力的变化。结果显示：随着受照剂量的增加，血液和肝细胞浆内总ＳＯＤ、铜锌ＳＯＤ、谷胱甘肽过氧化物酶和过氧化氢酶活力明显降低，而锰ＳＯＤ含量没有明显变化。血液和肝细胞浆内脂质过氧化物在受照大剂量组明显增加。上述结果提示：电离辐射对生物氧化酶活力有明显影响。其影响程度与受照剂量有关。受照后生物氧化酶活力降低是脂质过氧化物升高的主要原因。

This article reports the changes of bio-oxidase activities in cytoplasm of blood and liver cells from mice irradiated with different doses(3,6,9 and 12Gy).Experimental results showed that the total activities of superoxide dismutase,copper zinc superoxide dismutase,glutathione peroxidase and catalase in cytoplasm of blood and liver cells significantly decreased with increase of irradiation dosage,However,the actirity of manganese superoxide dismutase did not change under similar irradiation condion.The contents of lipid peroxidase in the blood and liver cells significantly increased in high dose irradiated group.These results demonstrate that the activities of bio-oxidase are significantly influenced by radiation damage.The extent of changes in bio-oxidase is related with radiation dosage.the main cause of the increase in lipid peroxidase is the decrease of bio-oxidase activities after irradiation.