正常人窦房结间质与年龄变化的相关研究

AGE-ASSOCIATED CHANGES IN THE INTERSTITIUM OF THE HUMAN SINOATRIAL NODE

应用网格测微器，半定量测定106例无明显心脏疾病之人体窦房结（SAN）纵切最大面积区域间质所占百分比，旨在探讨SAN间质变化与年龄递增的相互关系。结果：小于10岁，间质极少；11～20岁，间质所占百分比小于10％；21～40岁，为11％～25％；41～50岁，为26％～50％；51～60岁，为51／～75％；61～83岁，多于75％。40岁之前，SAN实质细胞与间质（以胶原纤维为主）均随年龄递增而逐渐增多；40岁后，SAN结细胞逐渐减少，间质相对变多，脂肪开始出现，呈现增龄性生理变化。

Using the sampling method parallel to the long axis of SAN, 106 forensic autopsy hearts without cardiac diseases were cut. The sections of 2μm thickness were stained with H. E and Betty's method.The percentag of the SAN interstitium in 7 age groups was estimated. Results:there is an increase in collagen,elastic fibers and fatty tissue with aging. Over 40,the actual area of SAN cells gradually de-crease,After 60 years of age,there is an infiltration of fat in the SAN.