RNAi及其抑制口蹄疫病毒复制的研究进展

RNA Interference and Its Application in FMDV

RNA干扰(RNA interference,RNAi)是指由双链RNA(double strand RNA,dsRNA)介导的序列特异的RNA降解过程。已经证明,在植物和昆虫细胞中RNAi是其主要的抗病毒免疫机制,至今为止几乎没有发现在病毒感染哺乳动物细胞过程中诱发有效的抗病毒RNAi反应。因此,人们希望能够利用人工方法在哺乳动物细胞中建立有效的抗病毒RNAi防御策略。迄今为止,对多种哺乳动物病毒的研究结果令人振奋。主要围绕RNAi的分子基础、基本策略及其在抑制口蹄疫病毒复制中的研究现状作了综述。

RNA interfence refers to the inhibition of gene expressio by dsRNA.RNAi has been proved as an antiviral mechanism in plants and insects instead of animals.People made great efforts to establish an eflqcaciously antiviral strategy in mammalians and have gained many exciting results. In this article,we review the current researches on molecular basis,basic strategy of the inhibition of virus replication by RNAi and its application in FMDV.