VEGF与VEGF-C蛋白在胆管癌中的表达及意义

Expression of vascular endothelial growth factor A and C in cholangiocarcinoma and their significance

目的探讨VEGF与VEGF-C蛋白在胆管癌的表达及其与临床病理特征的关系。方法采用免疫组化SP法检测49例胆管癌组织中VEGF与VEGF-C蛋白的表达。结果胆管癌VEGF和VEGF-C蛋白的表达率分别为65.3%和69.4%。VEGF和VEGF-C蛋白的高表达与胆管癌淋巴结转移及分化程度有关。VEGF与VEGF-C的表达有显著相关性(P<0.01)。结论VEGF和VEGF-C蛋白的表达与胆管癌侵袭转移有关。

[Objective] To investigate the relationship between expression and significance VEGF and VEGF- C in cholangiocarcinoma. [Methods] The expression of VEGF and VEGF-C was determined by immunohistochemical method in the 49 samples of cholangiocarcinoma. [Results] The rates of positive expression VEGF and VEGF-C were 65.3% and 69.4% in cholangiocarcinoma. The expression of VEGF and VEGF-C protein was correlated with tumor invasion,differentiation and lymph node metastasis. VEGF expression was significantly correlated with VEGE-C expression in hepatocellular carcinoma（ P 〈 0. 01）. [Conclusion] VEGF and VEGF-C played a role in invasion and metastasis of cholangiocarcinoma.