蜂蜜奶茶对小鼠应激性溃疡预防作用的实验研究

Experimental Study on Preventive Effect of Honey Milk Tea on Stress Gastric Ulcer

目的研究蜂蜜奶茶在保护胃粘膜、预防胃溃疡方面的作用效果,探讨蜂蜜奶茶的食疗价值。方法将小鼠分为三组,食疗组用蜂蜜奶茶25ml/kg·BW灌胃8d,并用蜂蜜奶茶代替蒸馏水饲养;药物组用雷尼替丁42mg/kg·BW灌胃8d,对照组用蒸馏水灌胃8d,后两组均用蒸馏水饲养,三组均食用相同的固体饲料。采用盐酸灌胃结合冷束缚模型,以18℃水温浸泡3h后取小鼠胃进行观察,统计诱导产生的溃疡数并分析统计结果。结果与对照组相比,药物组与食疗组平均溃疡指数均降低,溃疡抑制率分别为36.73%,64.00%,与对照组的差异均具有统计学意义。结论实验证明蜂蜜奶茶对应激性胃溃疡的发生有较好的预防作用,有较高的食用及应用价值,其作用机制还有待进一步研究。

Objective To study the preventive effect of honey milk tea on stress gastric ulcer, and to confirm the value of honey milk tea used as an alimentotherapy. Methods The mice were divided into three groups. The alimentotherapy group, was received honey milk tea, the medicine group received ranitidine, and the blank control group received distilled water. All the mice were treated in 8 successive days. We used the gastric ulcer model induced by HCI and restrained cryo- water - immersion stress, recorded the number of ulcer points and then analyzed the results after 3h immersion in 18℃ water. Results Compared with the blank control group, both the medicine and alimentotherapy groups had lower average ,ulcerative counts, and their suppressive ratios were 36.73 % and 64.00 % respectively （P〈 0.05）. Conclusion The results suggest that honey milk tea has a fairly preventive effect on stress gastric ulcer.