电针内关对偏头痛大鼠血浆中CGRP含量影响的研究

Research on the Effect of Electro-acupuncture of Neiguan on the CGRP Content in Migraine Rats' Plasma

[目的]研究电针内关对大鼠血浆中降钙素基因相关肽(CGRP)含量的影响及其作用机制。[方法]皮下注射硝酸甘油注射液(GTN),造成大鼠实验性偏头痛模型。电针内关治疗后,采用放射免疫法测定实验组大鼠血浆中CGRP的含量变化。[结果]电针内关能明显降低大鼠血中CGRP的含量。[结论]皮下注射GTN能使大鼠血中CGRP含量升高,电针内关可使升高的CGRP含量降低,调节血管扩张状态,改善神经源性炎症,从而使偏头痛症状得以缓解。

[Objective] To study the effect of eletro-acupuncture of Neiguan on the CGRP in rats＇ plasma and its functional mechanism. [Method] Inject subcutaneously GTN to make rats migraine model. After electro-acupuncturing Neiguan, take radio- immune method to measure the CGRP content in rats＇ plasma of experimental group. [Result] Electro-acupuncturing Neiguan can reduce rats CGRP content. [Conclusion] To inject subcutaneously GTN can raise rats＇ plasma CGRP content, electro-acupuncturing Neiguan can reduce risen CGRP, regulate vascular extension, improve nerve inflammation, thus relieve migraine symptoms.