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神经干细胞死亡的机制及改善策略 被引量：3

Mechanisms and improving strategies of neural stem cells death
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摘要 神经干细胞的研究一直是神经医学基础研究的热点之一，神经干细胞移植或促进自体脑内神经干细胞再生为治疗多种损伤性或退行性中枢神经系统疾病提供了新的希望．体外培养的胚胎或骨髓源性神经干细胞也为基因治疗提供了新的载体，但如何避免体外传代培养及移植后神经干细胞的衰退和死亡，维持其长期存活、发育、分化并行使功能依然是一个复杂而重要的问题。
作者 沈雪 马宏伟 徐如祥
机构地区 南方医科大学珠江医院神经医学研究所
出处 《中华神经医学杂志》 CAS CSCD 2007年第3期261-264,共4页 Chinese Journal of Neuromedicine
关键词 神经干细胞 神经元 细胞死亡 细胞凋亡
分类号 R686 [医药卫生—骨科学]
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参考文献27

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  • 2Sommer L, Rao M. Neural stem cells and regulation of cell number[J]. Prog Neurobiol, 2002, 66(1): 1-18.
  • 3Lin HJ, Wang X, Shaffer KM, et al. Characterization of H2O2-induced acute apoptosis in cultured neural stem/progenitor cells[J].FEBS Lett, 2004, 570(1-3): 102-106.
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同被引文献45

  • 1Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis[J]. Cell, 2008, 132(1): 45-60.
  • 2Gage FH. Mammalian neural stem cells [J]. Science, 2000, 287 (5457): 1433-1438.
  • 3Zhao M, Li D, Shimazu K, et al. Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis[J]. Biol Psychiatry, 2007, 62(5): 381-390.
  • 4Abrous DN, Koehl M, Le MM. Adult neurogenesis: from precursors to network and physiology[J]. Physiol Rev, 2005, 85(2): 523-569.
  • 5Barres BA, Raff MC. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons[J]. Nature, 1993, 361 (6409): 258-260.
  • 6Obrietan K, Gao XB, Van Den Pol AN. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism-a positive feedback circuit in developing neurons[J]. J Neurophysiol, 2002, 88(2): 1005-1015.
  • 7Lie DC, Colamarino SA, Song HJ, et al. Wnt signalling regulates adult hippocampalneurogenesis [J]. Nature, 2005, 437 (7063): 1370-1375.
  • 8Chen AE, Ginty DD, Fan CM. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins [J]. Nature, 2005, 433(7023): 317-322.
  • 9Kuhl M. The WNT/calcium pathway: biochemical mediators, tools and future requirements[J]. Front Biosci, 2004, 9(1): 967-974.
  • 10Engelhard K, Winkelheide U, Werner C, et al. Sevoflurane affects neurogenesis after forebrain ischemia in rats [J]. Anesth Analq, 2007, 104(4): 898-903.

引证文献3

二级引证文献7

中华神经医学杂志
2007年 第3期

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