无泵体外肺辅助技术对犬急性呼吸窘迫综合征血流动力学的影响

Effects of Pumpless Extracorporeal Lung Assist on Hemodynamics in The Canine Model With ARDS

目的探讨无泵型体外肺辅助技术(pECLA)对犬急性呼吸窘迫综合征(ARDS)模型血流动力学的影响,寻找安全的分流范围。方法建立犬ARDS模型,连接pECLA装置,将12只杂种犬随机分为两组,A组采用心排量的25%,20%,15%,10%的分流量顺序进行分流,B组采用心排量的10%,15%,20%,25%的分流量顺序进行分流,各分流量持续1小时,分别记录pECLA模型在模型建成后稳定一小时和各分流量末时的体循环血压,心率,肺循环血压。结果两组的体循环血压,心率,肺循环血压均有轻度变化,但无显著差异(P>0.05)。结论pECLA使用25%的分流量不会对血流动力学产生严重影响。

OBJECTIVE To find a safe shunt of cardiac output of pumpless extracorporeal lung assist （pECLA） in the canine model with acute respiratory distress syndrome （ARDS）. METHODS Twelve hybrid canines with ARDS were randomized to two groups, and were connected to pumpless extracorporeal lung assist. In group A, the shunt was 25%, 20% ,15% ,10% in turn. In group B,the shunt was 10% ,15% ,20% ,25%. All shunts were continuous for 1 hour. The artery pressure, heart rate and pulmonary artery pressure were recorded in each shunt end before the next shunt beginning. RESULTS There is no significant difference between all shunts and two groups in the artery pressure, heart rate and pulmonary artery pressure. CONCLUSION There is no overt disturbance on the hemodynamics in 25% shunt of cardiac output of pumpless extracorporeal lung assistance in the canine model with ARDS.