新穿心莲内酯治疗中暑作用的研究

Study on effect of neo-andrographolide against heat stroke

目的探讨中药穿心莲的有效成分新穿心莲内酯治疗中暑的疗效,为防治重症中暑提供实验依据。方法在干球温度(34.5±0.5)℃,相对湿度(60±5)%的条件下建立小鼠中暑模型,将小鼠随机分为新穿心莲内酯75、37.5、5、1 mg/kg组以及穿心莲内酯组、DMSO(二甲基亚砜)组、地塞米松组、生理盐水组和高温对照组,观察动物肛温上升速率和存活时间。结果与其他组比较,新穿心莲内酯5 mg/kg组动物肛温上升速率明显降低、存活时间显著延长。结论新穿心莲内酯是治疗中暑的有效药物,且5 mg/kg的给药量效果较好。

Objective To investigate the effect of neo-andrographolide on heat stroke and to provide a experimental evidence for the prevention and cure of the disease. Method Establishing the heat stroke model under such a circumstance that dry bulb temperature reached （34.5 ± 0.5） ℃ and the relative humidity reached （60 ± 5） %. 72 mice were randomly divided into nine groups including 4 neo- andrngrapholide groups （75, 37.5, 5 and 1 mg/kg）, ard^grapholide group, DMSO （dimethyl sulphoxide） group, dexanethasone group, normal saline group and heat stroke group. Then to observe the rise rate of anns-temperature and survival time of the mice. Re- sult Compared to other groups, the rise rates of anns-temperature and survival time in the mice of neo-andrographolide 5 mg/kg group were obviously slower and longer, respectively. Conclusion Neo-andrographohde, the effective element of a Chinese traditional herb, has a better effect against heat stroke, especially with the dose of 5 mg/kg.