抗菌药物静脉滴注给药方案的设计原理和方法

Dosage Regimen Design of Intravenous Infusion Administration of Antimicrobial Agents

目的设计抗菌药物静脉滴注给药方案。方法依据药物动力学和抗菌药物药效动力学原理,采用文献报道相关参数设计阿米卡星、环丙沙星和青霉素G静脉滴注给药方案。结果铜绿假单胞菌呼吸道感染患者给予阿米卡星380.64mg,静脉滴注速率33滴/min,每天给药1次;铜绿假单胞菌感染患者给予环丙沙星311.85mg,静脉滴注速率52滴/min,14h后给予第二剂量;化脓性链球菌感染患者给予青霉素G480万U,静脉滴注速率33滴/min,给药时间间隔12h。结论依据药物动力学和抗菌药物药效动力学原理,结合相关试验数据,可以设计静脉滴注给药方案。

Objective To establish a calculation of dosage regimen design of intravenous infusion administration of antimicrobial agents. Methods According to the relation of pharmarcokinetics and pharmarcodynamics, the dosage regimen of amikacin, ciprofloxacin and penicillin G were designed. Results The patient with respiratory tract infection of Ps. aeruginosa was administered amikacin in a dose of 380. 64 mg once daily by intravenous infusion, transfusion speed was 33 drops/min, or ciprofloxacin in a dose of 311.85 mg twicedaily, 52 drops/min; the patient with infection of S. pyogenes was administered penicillin G in a dose of 480 ten thousand U twice daily by intravenous infusion, transfusion speed was 33 drops/min. Conclusion According to the relation of pharmarcokinetics and pharmarcodynamics, the dosage regimen of intravenous infusion administration of antimicrobial agents may be designed.