摘要
目的：在低剂量照射条件下，合并化疗，以观察肿瘤细胞动力学变化。方法：应用０．０５ＧｙＸ射线对荷瘤鼠全身照射，结果：发现肿瘤细胞摄入３Ｈ—ＴｄＲ能力降低，Ｃ０／Ｇ１期细胞百分数增加，Ｓ期细胞百分数下降，Ｇ２期出现阻滞现象，且与对照组比较差异有显著性。低剂量辐射可增强丝裂霉素的化疗效果，导致肿瘤组织生长明显受抑。结论：上述结果证明：低剂量辐射可以抑制肿瘤细胞ＤＮＡ合成，诱导肿瘤细胞动力学改变，间接证实这种效应可促使肿瘤细胞向着程序化细胞死亡方向转变。且上述效应均有利于丝裂霉素的抗肿瘤作用。
The changes of carcinoma cell cycle distribution were induced in vitro and in vivo by low dose(0. 05Gy) X-ray irradiation. The percentages of the cells in G0/G1 phases tended to increase and that in S phase decreased. The extent of accumulation of cells in G1 phase was dose associated with programmed cell death (PCD) . It is indirectly showed in this study that low dose X-irradiation can impel the malignant cells to proceed to PCD. The result also demonstrated that low dose X - irradiation enhanced efficacy of mitomycin in killing malignant cells.
出处
《中华放射医学与防护杂志》
CSCD
北大核心
1996年第6期393-395,共3页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金
关键词
低剂量辐射
细胞动力学
丝裂霉素
肿瘤
Low dose irradiation
cell kinetics
mitomycin
programmed cell death
