睾丸中滞留的不同辐射体核素诱发生殖毒性比较研究

Comparative study on retentive peculiarity in testes and reproductive toxicity induced by different radiators

探讨了α辐射体浓缩铀（２３５Ｕ）、β辐射体（１４７Ｐｍ）和γ辐射体（１３４Ｃｓ）在睾丸的滞留特性，诱发生殖细胞精子畸形和精原细胞染色体畸变效应比较研究、，拟合了不同辐射体核素在睾丸中的滞留分数方程，观察到其半滞留期以２３５Ｕ为最长，１４７Ｐｍ次之，１３４Ｃｓ最短，其值分别为１９７天，７６天，５天。研究还给出了三种辐射体核素在每厘戈瑞累积吸收剂量水平诱发精子畸形的生殖毒性比较值α：β：γ为２８：３：１；而诱发精原细胞染色体畸变的生殖毒性比较值为２９：４：１。

In this paper a comparative study on retentive peculianties of different radiators in testes is reported. The equations fitted to describe the retentive fractions of α radiator￣(235)U and β radiator ￣(147)Pm as well as γ radiator￣(134)Cs respectively have been obtained. The half-life components were calculated to be T_(1/2)=197d for ￣(235)U, T_(1/2)= 76d for ￣(147)Pm, and only 5. 1d for￣(134)Cs.Comparative study on reproductive toxicity induced by different radiators showed that internal contamination with different radiators could result in sperm abnormality. For different radiators such as ￣(235)U, ￣(147)Pm and ￣(134)Cs, the rates of sperm abnormality induced by 1 cGy cumulative absorption dose were different: the comparative value of reproductive toxicity was α: β:γ= 28 : 3 : 1. Results indicated that internal contamination by different radiatore could damage genetic materials and cause chromosome aberrations in spermatogonia. By comparison between different radiators, the frequencies of chromosome aberrations induced by 1cGy cumulative absorption dose were significantly different: the comparative value of reproductive toxicity was α: β: γ= 29 : 4 :1 .