加替沙星7日疗法治疗43例急性尿路感染的临床评价

Clinical evaluation of gatifloxacin treatment for 7 days in 43 patients with acute urinary tract infection

目的:评价加替沙星治疗急性尿路感染的有效性和安全性。方法:将86例临床确诊为急性尿路感染的患者随机分为2组:试验组(加替沙星组)43例,口服加替沙星胶囊400 mg,1次/d;对照组(头孢克洛组)43例,口服头孢克洛胶囊250 mg,3次/d,疗程均为1周。结果:试验组与对照组总有效率分别为95.3%和93.0%。细菌清除率分别为94.6%和88.6%。药物不良反应发生率分别为7.0%和9.3%。结论:加替沙星7日疗法是治疗急性尿路感染安全、有效的临床治疗方法之一。

Objective： To evaluate the effectiveness and safety of gatifloxacin compared with cefaclor in the treatment of acute urinary tract infection. Methods： Eighty-six patients with acute urinary tract infection were randomized into gatifloxacin group （GAT, 400 mg,po,qd） and cefaclor group （CEF, 250 mg,po,tid ）. Each group had 43 patients. The therapy lasted 7 days. Results： The overall clinical effective rates of GAT and CEF groups were 95.3% and 93.0%, respectively. The bacteria clearance rates of two groups were 94.6% and 88.6%, and the incidences of adverse drug reactions were 7.0% and 9.3%, respectively. Conclusion： Gatifloxacin treatment for 7 days is one of the safe and effective methods for treating acute urinary tract infection.