摘要
用一组雌激素相关标志对54例女性乳腺癌进行回顾性研究。患者平均47．9岁，5年生存率为81.5％。癌肿长径平均3．4cm，浸润性导管癌49例，Ⅲ级36例。肿瘤大小、组织学类型、分级与预后关系不明显。ER阳性率55．6％，PR阳性率389％，与组织蛋白酶D有较好相关性。组织蛋白酶D在癌细胞的阳性年为278％，间质巨噬细胞阳性率为100％，与ER、PR关系较密切，并与预后相关。
A group of estrogen-related markers were employed to study breast carcInoma retrospectively in 54 women with the average age of 47. 9. The 5-year-survial rate were 81. 5%. The mean length of the breast tumors was 3. 4cm. There were invasive ductal carcinoma in 49 cases and high grade rnalignancies in 36 cases. No significcnt relationship between the prognosis and the tumor size, his tological typing or grading was found. The positive rate of estrogen receptor(ER) was 55. 6% and progesterone receptDr(PR), 38. 9%,which were related to cathepsin D. Cathepsin D expressed in tumor cells were found in 15 cases (27. 8 % ) and intetstitial macrophages,in all cases, which were close associated with ER, PR and also related to the prognosis.
关键词
乳腺肿瘤
雌激素受体
孕激素受体
预后
Breast neoplasms
Estrogen receptors(ER)
Progesterone receptors(PR)
Cathepsin D
Prognosts
