复合离子盐及α-内收蛋白ADD1基因多态性对高血压患者血压及相关因素的影响

Effects of the lower salt intake and α-adducin gene polymorphism on blood pressure and associated factors in hypertensive patients

【目的】观察复合离子盐及α-内收蛋白ADD1基因多态性对高血压患者血压、血脂及尿电解质的影响。【方法】根据入选标准纳入天津市111例高血压患者,随机分为摄入普通盐组和复合离子盐组,随访1年,测量血压、血脂、肌酐、尿钠和尿钾排泄量等相关指标。α-内收蛋白ADD1基因多态性的分型运用聚合酶链式技术进行分析。【结果】与普通盐组相比,随访终点复合离子盐组收缩压平均水平和尿钠排泄量降低(P<0.05);两组血脂比较无统计学差异(P>0.05)。α-内收蛋白460Trp等位基因在本研究中出现的频率为33%,比较复合离子盐组ADD1不同基因型血压、血脂和尿电解质水平无统计学差异。【结论】低钠高钾盐可降低高血压人群的收缩压及尿钠排出量。

To investigate the effect of low sodium high potassium salt intake and a-adducin gene polymorphism on the hypertensive petient. [Methods] According to the inclusion and exclusion criteria, 111 hypertensives were involved in this study. They were randomized into common salt intake group and low sodium salt group for 12 months after a 4 weeks introduction stage. The α-adducin Gly-460-Trp polymorphism was investigated by polymerase chain reaction amplification of genomic DNA. [Results] Systolic blood pressure （SBP） and the urinary sodium was significantly lower in the lower salt intake group than in the common salt intake group （ P 〈 0.05）. Serum TC, TG and HDL did not signif- icantly changed in both low salt group and normal salt group （ P 〉 0.05）. The frequency of α-adducin 460 Trp allele was 33% in hypertensives in this study. No significant association was found between different α-adducin genotypes and BP and urinary electrolytes in group of lower salt intake. [Conclusion] Low sodium high potassium salt may be a feasible means of lowering SBP and urine sodium.