摘要
目的:探讨肿瘤坏死因子α(TNF-α)基因启动子区多态性与乙型肝炎病毒(HBV)持续感染或清除的关系.方法:通过检索PubMed、Embase以及CNKI共纳入18项病例对照研究,采用荟萃分析方法研究TNF-α基因启动子区基因多态性与HBV持续感染或清除的关系,以及采用荟萃回归分析不同研究之间存在异质性的原因.结果:亚洲人群(蒙古人种)中自然痊愈组(904例)-308G/A位点的基因型(GA+AA)频率显著高于持续HBV感染组(2303例)(P=0.001),而欧洲人(高加索人种)中持续HBV感染组(256例)-238G/A位点的基因型(GA+AA)频率略高于自然痊愈组(195例)(P=0.07),样本量、种族、地区以及研究方法均为影响不同研究之间异质性的因素(P<0.05),使研究之间总变异效应降低了约0.236.结论:TNF-α-308G/A位点多态性可能与感染HBV后的清除有关,而-238G/A位点多态性可能与HBV的持续感染有关,并且样本量、种族、地区以及研究方法因素均可能影响病例对照研究的结果.
AIM： To investigate the relationship between the polymorphisms of tumor necrosis factor-α （TNF-α） gene promoter and hepatitis B virus （HBV） infection.
METHODS： A total of 18 case-control studies were indexed from PubMed, Embase and CNKI database, and meta-analysis and metaregression analysis were performed to explore the relationship between the polymorphisms of TNF-α gene promoter and HBV infection as well as the differences between each study.
RESULTS： The frequency of genotype （TNF-α- 308A/G and A/A） was significantly higher in spontaneously recovered group （904 controls） as compared with that in persistent HBV infection group （2303 cases） in Asian population （Mongoloid） （P = 0.001）. In European population （Caucasian）, the frequency of genotype （TNF-α-238A/ G and A/A） was slightly higher in persistent HBV infection group （256 cases） as compared with that in spontaneously recovered group （195 controls） （P = 0.07）. The ethnicity, sample size, genotyping procedure and geographical location were the influential factors in the case-control study, and the estimated between-study variance was reduced by 0.236.
CONCLUSION： The presence of the genotype （TNF-α-238A/G and A/A） may be associated with persistent HBV infection, while the genotype （TNF-α-308A/G and A/A） may be associated with HBV clearance. The ethnicity, sample size, genotyping procedure and geographical location are factors influencing the results of casecontrol study.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第6期580-584,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金
No.30671855~~
