药物缓释材料聚磷酸酯-聚乳酸的直接熔融聚合法合成工艺研究

Study on direct synthesis of drug delivery carrier material polyphosphate ester-polylactic acid via melt polycondensation

以外消旋乳酸(D,L-LA)、乙二醇和二氯磷酸苯酯为原料,通过熔融聚合法直接合成生物降解材料聚磷酸酯-聚乳酸,用凝胶渗透色谱测定产物的相对分子质量,探讨了预聚方式、催化剂种类和用量,以及熔融聚合反应时间、反应温度对共聚物相对分子质量的影响。在160℃、70Pa、催化剂ZnO的用量0.5%的条件下熔融聚合8h,共聚物的重均分子量可达9200,可以用于药物缓释微球。新合成方法有利于降低聚磷酸酯-聚乳酸作为药物缓释载体材料的合成成本。

Starting from D,L-lactic acid （D,L-LA）, ethylene glycol （EG） and phenyl dichlorophosphate （PDP）, biodegradable material polyphosphate ester-polylactic acid was directly synthesized via melt polycondensation. The copolymer was characterized with GPC, and the influences of different synthetic conditions, including the prepolymerization method, kinds and quantity of catalyst, melt copolycondensation time and temperature on the weight average molecular （Mw） of copolymer were discussed in detail. When catalyzed by 0. 5% （weight percent） ZnO under 160℃ and 70Pa, 8h＇s copolymerization gave the copolymer with maximum Mw 9200. The relative molecular weight can meet the requirement of drug delivery microsphere. The novel synthetic method is beneficial to reduce the synthesis cost of polyphosphate esterpolylactic acid as drug delivery carrier material.