乳腺癌患者血清中期因子检测及意义

Determination of Serum MK in Patients with Breast Cancer and Its Clinical Significance

目的评价血清肿瘤标志物中期因子(MK)在乳腺癌中的临床价值。方法采用酶联免疫吸附法对20例正常女性,20例女性乳腺良性疾病和64例乳腺癌患者血清MK进行检测。结果正常人血清MK含量均值为431.40 pg/mL,以484.78 pg/mL为正常阈值,其假阳性率为5%;乳腺良性肿瘤对照组MK含量平均为444.55±22.22 pg/mL,其假阳性率为5%;乳腺癌血清MK含量平均为709.80±126.32 pg/mL,其阳性率为84.4%。Ⅰ、Ⅱ、ⅢI、V期血清MK值分别为490.83±22.94 pg/mL、725.00±102.62 pg/mL、795.67±91.82 pg/mL、976.50±76.49 pg/mL。阳性率分别为33.3%、91.7%、91.8%、100.0%。手术后血清MK值及阳性率较术前有明显下降。结论血清MK检测在乳腺癌的诊断、鉴别诊断,特别是监测疗效与癌复发转移有较高临床应用价值。

Objective To evaluate the clinical significance of serum MK in patients with breast cancer. Methods The MK levels in serum were determined with enzyme - linkedimmunosorbent assays for 20 healthy women,20 patients with breast benign diseases and 64 patients with breast cancer. Results The serum level of MK in healthy women was 431.40 ± 26.69 pg/mL with a false positive rate of 5 % based on the cut - off value of 484.78 pg/mL . In 20 patients with benign breast diseases the serum level was 444.55 ±22.22 pg/mL with a false positive rate of 5%. In 64 cases of breast cancer was 709.80 ± 126.32 pg/mL with a positive rate of 84.4%. The recurrences and metastases with breast cancer caused a significant elevation of serum MK, with 100% positive rate. Condusions The detennination of MK in serum is highly useful in the diagnosis, differential diagnosis, especially in monitoring the metastases and recurrences of breast cancer.