拉米夫定联合MARS治疗慢性重型乙型肝炎疗效观察

The Effect of Lamivudine Combined With MARS in the Treatment of Chronic Fulminant Hapatitis B

目的观察拉米夫定联合分子再吸附循环系统(MARS)对慢性重型乙型肝炎的治疗效果。方法将40例慢性重型乙型肝炎患者随机分成治疗组和对照组,在内科综合及MARS治疗基础上,治疗组联合应用拉米夫定,通过比较两组临床症状、TB(总胆红素)、PTA(凝血酶原活动度)及HBV DNA含量,了解拉米夫定的治疗效果。结果治疗组在改善TB、PTA及提高治疗有效率、HBV DNA阴转率方面较对照组差异有显著性(P<0.05)。结论拉米夫定在MARS等的治疗基础上可能能够进一步提高对慢性重型乙型肝炎患者的治疗效果。

Objective To study the effect of lamivudine combined with molecular adsorbent recycling system （ MARS） in the treatment of chronic fulminant hepatitis B. Methods 40 patients with the chronic fulminant hepatitis B were randomly divided into two groups. Patients in one group was given lamivudine, based on MARS and other treatment, while the control group was given the same treatment without lamivudine. The main symptoms, TB, PTA, and HBV DNA were investigated after treatment. Results Significant differences were found between the two groups for the TB and PTA change, HBV DNA loss and the effective ratio. Condusions Lamivudine can improve the effects further based on MARS treatment in the treatment of chronic fulminant hepatitis B probably.