摘要
目的探讨多发性骨髓瘤患者血清M蛋白的特性并进行分型鉴定。方法对28例血清蛋白电泳异常的患者血清进行免疫固定电泳、血清蛋白和免疫球蛋白分析。结果28例多发性骨髓瘤患者中,IgG型18例(64.3%),其中κ轻链型7例,λ轻链型11例;IgA型5例(17.9%),其中κ轻链型4例,λ轻链型1例;单纯轻链型2例(7.1%),均为λ轻链型;不分泌型3例(10.7%),均为κ轻链型。血清总蛋白升高者20例,球蛋白升高者24例。免疫球蛋白和轻链检测表明同型免疫球蛋白和轻链其含量多明显升高并常伴有其它组份的异常。结论应用免疫固定电泳对多发性骨髓瘤患者的M蛋白进行分型鉴定特异性好、灵敏度高,对多发性骨髓瘤的诊断分型和临床分期及预后具有重要意义。
Objective To evaluate the characteristics of serum M protein in patients with multiple myeloma and study the application of immunofixation electrophoresis in typing M proteins. Methods 28 abnormal sera samples with serum electrophoresis were detected by serum immunofixation electrophoresis, serum electrophoresis and quantitative analysis of immunoglobulins. Results Of all the patients, there were 7 cases of IgGk, 11 IgG λ, 4I gA to, 1 IgA λ, 2 λ, light chains and 3 k unsecretarial myelomas. Serum total protein of 20 samples increased, serum globulin protein of 24 cases also increased. Immunoglobulin protein and light chain of the same type increased meanwhile, and followed by abnomality of other components. Conclusion Serum immnunofixation electrophoresis showes excellent high sensitivity and specificity in the determination and classification of multiple myeloma, and can be used in diagnosising multiple myeloma and typing M proteins.
出处
《南华大学学报（医学版）》
2007年第1期107-109,共3页
Journal of Nanhua University(Medical Edition)
关键词
多发性骨髓瘤
免疫固定电泳
M蛋白
multiple myeloma
immunofixation electrophoresis
M proteins
