摘要
为探讨复方太子参颗粒对失神经支配骨骼肌萎缩的影响,用切断SD大鼠右侧胫神经的方法建立失神经支配骨骼肌萎缩的动物模型。将造模后的SD大鼠随机分为实验组和对照组。实验组每天每只大鼠以含复方太子参颗粒1g的生理盐水溶液3ml灌胃;对照组每天每只大鼠以生理盐水3ml灌胃。于术后2、4、6周取大鼠腓肠肌,称量肌湿重,测定肌肉蛋白质。结果术后大鼠腓肠肌明显萎缩,腓肠肌湿重进行性下降,实验组肌湿重显著大于对照组。失神经支配后,骨骼肌总蛋白含量逐渐减少,实验组肌肉总蛋白含量显著大于对照组。表明复方太子参颗粒可以延缓失神经支配骨骼肌的萎缩,其可能机制是抑制失神经支配后肌肉蛋白质的分解;周围神经损伤后,周围神经的手术修复越早,术后功能恢复越好。
In order to study the effect of “FUFANG TAIZISHEN KELI”(TZS, TCD granula for treating muscle atrophy )on denervated muscle atrophy of rat, SD rat-models made by cutting off the right tibial nerve were randomly divided into the treated and control groups, which were treated by TZS solution (1g/3ml) and by physiological saline(3ml), respectively; green-weight and muscle protein of gastrocnemius in 2, 4, 6 weeks after operation were measured respectively and compared. The results showed that gastrocnemius of both two groups were progressive atrophy, but the green-weight and muscle protein of treated group in 2, 4, 6 weeks were all apparently higher than those of control group (P<0.05), suggesting that the TZS has a good function to wait denervated muscle atrophy of rat and inhibiting proteolysis is viewed as the possible mechanism, so peripheral nerve should be restored as soon as possible after injured.
出处
《中医正骨》
2007年第3期4-6,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
基金
福建省科技厅重点项目基金(99-Z139)
福建省科技三项费用基金(K20066)
